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Lora FM (Loratadine)
- Lora FM is (Loratadine) in the form of fast melt tablets
- Lora FM is a second generation peripheral histamine H1-receptor blocker used to treat allergies. Loratadine is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system
- Lora FM is marketed for its non-sedating properties
- Lora FM is a tricyclic anti-histamine, which acts as a selective inverse agonist of peripheral histamine H1-receptors. Histamine is responsible for many features of allergic reactions
- “FM “ stands for Fast Melting formulation, an Orally Disintegrated Tablet (O.D.T.), specially manufactured using the Pharmaburst Technology
- This Pharmaburst technology helps in the rapid disintegration of the tablet within the mouth, offering a quick onset of action with smooth creamy mouth feeling in peppermint flavor
- Lora FM for oral administration is marketed in a pack of 10 tablets
- The most potent & active fluoroquinolone anti-bacterial agent for:
- Acute exacerbations of chronic bronchitis
- Acute bacterial sinusitis
- Community acquired pneumonia
- Skin and skin structure infections
- Complicated intra-abdominal infections
- Moxiflox is (Moxifloxacin) in the form of film coated tablets
- Moxiflox is a fourth-generation synthetic fluoroquinolone anti-bacterial agent
- Moxiflox antibacterial spectrum includes enteric Gram-(−) rods (Escherichia coli, Proteus species, Klebsiella species), Haemophilus influenzae, atypical bacteria (Mycoplasma, Chlamydia, Legionella), and Streptococcus pneumoniae, and anaerobic bacteria. It differs from earlier anti-bacterials of the fluoroquinolone class such as levofloxacin and ciprofloxacin in having greater activity against Gram-positive bacteria and anaerobes
- Moxiflox is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell replication
- Moxiflox 400 mg for oral administration is marketed in a pack of 5 or 7 tablets
- The most active - rapid analgesic, anticonvulsant, and anxiolytic for Neuropathic pain, Fibromyalgia, and Generalized Anxiety Disorders
- Neurogab is (Pregabalin) in the form of Capsules
- Neurogab is β-isobutyl-γ-aminobutyric acid (beta-isobutyl-GABA), a medication used to treat neuropathic pain, fibromyalgia, and generalized anxiety disorder. Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults
- Neurogab is a derivative of the neurotransmitter γ-aminobutyric acid (GABA) and a potent gabapentinoidn. It is a ion channel modulator that has rapid analgesic, anticonvulsant, and anxiolytic effects. Pregabalin is also a central nervous system depressant
- Neurogab binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. Although, pregabalin is an analogue of GABA, it does not bind directly to GABAA, GABAB, or benzodiazepine receptors. Nor does it block sodium channels and is not active at opioid receptors. Gabapentinoids, such as pregabalin, are α2δ subunit voltage-gated calcium channel modifiers that affect GABA. Neurogab is approximately 2.5 times more potent and binds more strongly to the receptors than gabapentin
- Neurogab 75 mg & 150 mg for oral administration are marketed in packs of 30 capsules
- An atypical antipsychotic, recommended and primarily used in the treatment of Schizophrenia, Bipolar Disorder and an add on treatment in Major depressive disorder.
- Aripex is ( Aripiprazole) in the form of tablets
Other uses include tic disorders, and irritability associated with autism.
- Aripex mechanism of action is different from those of the other FDA-approved atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, ziprasidone, and risperidone). Rather than antagonizing the D2 receptor, Aripex acts as a D2 partial agonist. It is a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics displays an antagonist profile at the 5-HT2A receptor . It also antagonizes the 5-HT7 receptor and acts as a partial agonist at the 5-HT2C receptor, both with high affinity. Aripex acts by modulating neurotransmission over activity on the dopaminergic mesolimbic pathway, which is thought to be the cause of positive schizophrenia symptoms. Due to its agonist activity on D2 receptors, Aripex may also increase dopaminergic activity to optimal levels in the mesocortical pathways where it is reduced
- Aripex 5 mg, 10 mg & 15 mg for oral administration are marketed in packs of 30 capsules
Goutex is a novel, xanthine oxidase/dehydrogenase (XO/XDH) inhibitor, indicated in patients with gout suffering from hyperuricemia and is used in its chronic management.
Mechanism of Action
Uric acid is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine Xanthine uric acid. Both steps in the above transformations are catalyzed by xanthine oxidase (XO). Febuxostat is a 2-arylthiazole derivative that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting XO. Goutex is a potent, non-purine selective inhibitorof XO (NP-SIXO) with an in vitro inhibition Ki value less than one nanomolar. Goutex has been shown to potently inhibit both the oxidized and reduced forms of XO.
At therapeutic concentrations Goutex does not inhibit other enzymes involved in purine or pyrimidine metabolism, namely, guanine deaminase, hypoxanthine guanine phosphoribosyl transferase, orotate phosphoribosyl transferase, rotidine monophosphate decarboxylase or purine nucleoside phosphorylase.